%0 Journal Article %T The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis %+ Institut de Biologie François JACOB (JACOB) %+ Mahidol University [Bangkok] %+ Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) %+ Hôpital Européen Georges Pompidou [APHP] (HEGP) %+ Université Paris Descartes - Paris 5 (UPD5) %+ Brigham and Women's Hospital [Boston] %+ Harvard Medical School [Boston] (HMS) %A Goupille, O %A Penglong, T %A Kadri, Z %A Granger-Locatelli, M %A Denis, R %A Luquet, S %A Badoual, C %A Fucharoen, S %A Maouche-Chretien, L %A Leboulch, P %A Chretien, S %< avec comité de lecture %@ 2211-1247 %J Cell Reports %I Elsevier Inc %V 21 %N 12 %P 3524-3535 %8 2017 %D 2017 %R 10.1016/j.celrep.2017.11.098 %M 29262331 %K GATA TRANSCRIPTION FACTORS %K ZINC-FINGER PROTEINS %K DIET-INDUCED OBESITY %K ENERGY-EXPENDITURE %K ADIPOSE-TISSUE %K BROWN FAT %K LACTATE %K DIFFERENTIATION %K WHITE %K EXPRESSION %Z Life Sciences [q-bio]Journal articles %X GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown fat conversion. Thus, each component of the GATA/FOG complex (GATA-1 and FOG-2) is involved in pRb/E2F regulation, but these molecules have markedly different roles in the control of tissue homeostasis. %G English %2 https://cnrs.hal.science/hal-03108274/document %2 https://cnrs.hal.science/hal-03108274/file/PIIS2211124717317801.pdf %L hal-03108274 %U https://cnrs.hal.science/hal-03108274 %~ INSERM %~ CEA %~ UNIV-PARIS5 %~ CNRS %~ APHP %~ USPC %~ JACOB %~ CEA-DRF %~ CHU-UNIV-PARIS5 %~ UNIV-PARIS %~ UP-SCIENCES %~ BFA