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            <title xml:lang="en">Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP</title>
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                <forename type="first">Petya</forename>
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                <title xml:lang="en">Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP</title>
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                <title level="j">Protein Science</title>
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                <term xml:lang="en">c-di-GMP receptors</term>
                <term xml:lang="en">Diguanylate cyclase</term>
                <term xml:lang="en">Phosphodiesterase</term>
                <term xml:lang="en">Structural Biology</term>
                <term xml:lang="en">Intracellular signaling</term>
                <term xml:lang="en">Biofilm formation</term>
                <term xml:lang="en">c-di-GMP signaling</term>
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              <p>An intracellular second messenger unique to bacteria, c-di-GMP, has gained appreciation as a key player in adaptation and virulence strategies, such as biofilm formation, persistence, and cytotoxicity. Diguanylate cyclases containing GGDEF domains and phosphodiesterases containing either EAL or HD-GYP domains have been identified as the enzymes controlling intracellular c-di-GMP levels, yet little is known regarding signal transmission and the sensory targets for this signaling molecule. Although limited in number, identified c-di-GMP receptors in bacteria are characterized by prominent diversity and multilevel impact. In addition, c-di-GMP has been shown to have immunomodulatory effects in mammals and several eukaryotic c-di-GMP sensors have been proposed. The structural biology of c-di-GMP receptors is a rapidly developing field of research, which holds promise for the development of novel therapeutics against bacterial infections. In this review, we highlight recent advances in identifying bacterial and eukaryotic c-di-GMP signaling mechanisms and emphasize the need for mechanistic structure-function studies on confirmed signaling targets.</p>
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