Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue eLife Année : 2017

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

Résumé

A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contributing to goal-directed behaviors. However, whether aversion encoding requires these neural circuits to ultimately prompt escape behaviors remains unclear. We observe that aversive stimuli, including foot-shocks, excite LHb neurons and promote escape behaviors in mice. The foot-shock-driven excitation within the LHb requires glutamatergic signaling from the LH, but not from the midbrain. This hypothalamic excitatory projection predominates over LHb neurons monosynaptically innervating aversion-encoding midbrain GABA cells. Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driven escape behaviors. These findings unveil a habenular neurocircuitry devoted to encode external threats and the consequent escape; a process that, if disrupted, may compromise the animal’s survival.
Fichier principal
Vignette du fichier
elife-30697-v2.pdf (2.65 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03129952 , version 1 (03-02-2021)

Identifiants

Citer

Salvatore Lecca, Frank J Meye, Massimo Trusel, Anna Tchenio, Julia Harris, et al.. Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior. eLife, 2017, 6, pp.e30697. ⟨10.7554/eLife.30697⟩. ⟨hal-03129952⟩
11 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More