Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19 - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue International Archives of Allergy and Immunology Année : 2021

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Jean Bousquet
Wienczyslawa Czarlewski
Torsten Zuberbier
Joaquim Mullol
Hubert Blain
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Rafael de La Torre
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Nieves Pizarro Lozano
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Vincent Le Moing
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Anna Bedbrook
Ioana Agache
Cezmi Akdis
G. Walter Canonica
Alvaro Cruz
Alessandro Fiocchi
Joao Fonseca
Susana Fonseca
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Bilun Gemicioğlu
Tari Haahtela
Guido Iaccarino
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Juan Carlos Ivancevich
Marek Jutel
Ludger Klimek
Helga Kraxner
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Piotr Kuna
Désirée Larenas-Linnemann
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Adrian Martineau
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Erik Melén
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Yoshitaka Okamoto
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Nikolaos Papadopoulos
Oliver Pfaar
Frederico Regateiro
Philip Rouadi
Boleslaw Samolinski
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Aziz Sheikh
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Sanna Toppila-Salmi
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Arunas Valiulis
Hak-Jong Choi
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Hyun Ju Kim
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Josep Anto
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Résumé

In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
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Dates et versions

hal-03140042 , version 1 (12-02-2021)

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Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, et al.. Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19. International Archives of Allergy and Immunology, In press, ⟨10.1159/000514204⟩. ⟨hal-03140042⟩
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