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Article Dans Une Revue Communications Biology Année : 2021

Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

Résumé

In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central role in cell entry. We designed a series of peptides mimicking the N-terminal helix of hACE2 protein which contains most of the contacting residues at the binding site, exhibiting a high helical folding propensity in aqueous solution. Our best peptide-mimics are able to block SARS-CoV-2 human pulmonary cell infection with an inhibitory concentration (IC 50) in the nanomolar range upon binding to the virus spike protein with high affinity. These first-in-class blocking peptide mimics represent powerful tools that might be used in prophylactic and therapeutic approaches to fight the coronavirus disease 2019 (COVID-19).

Domaines

Immunologie
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Origine : Publication financée par une institution

Dates et versions

hal-03141346 , version 1 (15-02-2021)

Identifiants

Citer

Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, et al.. Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. Communications Biology, 2021, 4 (1), pp.197. ⟨10.1038/s42003-021-01736-8⟩. ⟨hal-03141346⟩
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