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Article Dans Une Revue Evolutionary Applications Année : 2021

Identifying key questions in the ecology and evolution of cancer

1 Deakin University [Waurn Ponds]
2 MIVEGEC-CREEC - Centre de Recherches Ecologiques et Evolutives sur le Cancer
3 ASU - Arizona State University [Tempe]
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
6 Johns Hopkins University School of Medicine [Baltimore]
7 UC - University of California
8 H. Lee Moffitt Cancer Center and Research Institute
9 TBI - Toulouse Biotechnology Institute
10 University of Colorado [Colorado Springs]
11 University of Louisville
12 The institute of cancer research [London]
13 LIENSs - LIttoral ENvironnement et Sociétés
14 UTAS - University of Tasmania [Hobart, Australia]
15 Penn State - Pennsylvania State University
16 The Francis Crick Institute [London]
17 UNB - University of New Brunswick
18 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
19 UZH - Universität Zürich [Zürich] = University of Zurich
20 UC Riverside - University of California [Riverside]
21 Dana-Farber Cancer Institute [Boston]
22 HSDM - Harvard School of Dental Medicine [Boston]
23 SU - Sorbonne Université
24 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
25 IGR - Institut Gustave Roussy
26 Université Paris-Saclay
27 Département d'hématologie [Gustave Roussy]
28 CSHMyelo - U1287 Inserm - Cellules souches hématopoïétiques et développement des hémopathies myéloïdes
29 Maastricht University [Maastricht]
30 TU Delft - Delft University of Technology
Jean‐pascal Capp
Paul Ewald
Carlo Maley
Michael J Metzger
  • Fonction : Auteur
  • PersonId : 1057655
Holly Swain Ewald
Beata Ujvari

Résumé

The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco-evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed. Here, we aim to assess current advancements in the field and to suggest future directions for research. First, we summarize cancer research areas that, so far, have assimilated ecological and evolutionary principles into their approaches and illustrate their key importance. Then, we assembled 33 experts and identified 84 key questions, organized around nine major themes, to pave the foundations for research to come. We highlight the urgent need for broadening the portfolio of research directions to stimulate novel approaches at the interface of oncology and ecological and evolutionary sciences. We conclude that progressive and efficient cross-disciplinary collaborations that draw on the expertise of the fields of ecology, evolution and cancer are essential in order to efficiently address current and future questions about cancer.
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hal-03164823 , version 1 (10-03-2021)

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Antoine M Dujon, Athena Aktipis, Catherine Alix-Panabières, Sarah R Amend, Amy M Boddy, et al.. Identifying key questions in the ecology and evolution of cancer. Evolutionary Applications, 2021, 14 (4), pp.877-892. ⟨10.1111/eva.13190⟩. ⟨hal-03164823⟩
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