Developing a MEMS device for high-throughput multi-parameter single cell biophysical analysis - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Communication Dans Un Congrès Année : 2021

Developing a MEMS device for high-throughput multi-parameter single cell biophysical analysis

Résumé

We introduced a MEMS device to perform direct measurements on electrical and mechanical properties of single cancer cells. Working in a continuous flow format permits high-throughput measurements. The device design allows us to define fixed or movable electrodes as part of the side-walls of an embedded microchannel. The stable air-liquid interface at micro-sized gaps between the electrodes and the channel wall provide flow continuity without causing any leakage problems. This unified processing approach allows us to define optimized electrode pattern configuration for both electrical and mechanical characterization areas. Moreover, the movable electrode is in direct contact with passing cells which enables direct sensing during compression. The device can perform both electrical and mechanical measurements on single cells in a continuous flow as demonstrated and also validated by optical control measurements. The proposed method aims at providing high-throughput biophysical cytometry, in an optics- and marker-free way, for cancer cell evaluation.
Fichier principal
Vignette du fichier
Rezard_2021_Developing_A_Mems_Device_for_High-Throughput_Multi-Parameter_Single_Cell_Biophysical_Analysis.pdf (1.02 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03195317 , version 1 (17-09-2021)

Identifiants

Citer

Quentin Rezard, Gregoire Perret, Jean Claude Gerbedoen, Deniz Pekin, Fabrizio Cleri, et al.. Developing a MEMS device for high-throughput multi-parameter single cell biophysical analysis. 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems, MEMS 2021, Jan 2021, Gainesville (on line), United States. pp.494-497, ⟨10.1109/MEMS51782.2021.9375176⟩. ⟨hal-03195317⟩
140 Consultations
97 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More