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Article Dans Une Revue Magnetic Resonance in Chemistry Année : 2021

Solid state NMR spectroscopy as a powerful tool to investigate the location of fluorinated lipids in highly porous hybrid organic-inorganic nanoparticles

Résumé

Nanosized metal-organic frameworks (nanoMOFs) have emerged as a new class of biodegradable and non-toxic nanomaterials of high interest for biomedical applications thanks to 2 the possibility to load large amounts of a wide variety of therapeutic molecules in their porous structure. The surface of the highly porous nanoMOFs is usually engineered to increase their colloidal stability, tune their interactions with the biological environment and allow targeting specific cells or organs. However, the atomic-scale analysis of these complex core-shell materials is highly challenging. In this study, we report the investigation of aluminium-based nanoMOFs containing two fluorinated lipids by solid-state NMR spectroscopy, including 27 Al, 1 H and 19 F MAS NMR. The ensemble of NMR data provides a better understanding of the localization and conformation of the fluorinated lipids inside the pores or on the nanoMOF surface.

Domaines

Chimie
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Dates et versions

hal-03195336 , version 1 (11-04-2021)

Identifiants

Citer

Marianna Porcino, Xue Li, Ruxandra Gref, Charlotte Martineau‐corcos. Solid state NMR spectroscopy as a powerful tool to investigate the location of fluorinated lipids in highly porous hybrid organic-inorganic nanoparticles. Magnetic Resonance in Chemistry, 2021, 59 (9-10), pp.1038-1047. ⟨10.1002/mrc.5148⟩. ⟨hal-03195336⟩
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