%0 Journal Article %T sAOP: linking chemical stressors to adverse outcomes pathway networks %+ University of Copenhagen = Københavns Universitet (UCPH) %+ Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124) %+ Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) %A Aguayo-Orozco, Alejandro %A Audouze, Karine %A Siggaard, Troels %A Barouki, Robert %A Brunak, Soren %A Taboureau, Olivier %< avec comité de lecture %@ 1367-4803 %J Bioinformatics %I Oxford University Press (OUP) %V 35 %N 24 %P 5391-5392 %8 2019 %D 2019 %R 10.1093/bioinformatics/btz570 %M 31329252 %Z Life Sciences [q-bio]Journal articles %X Motivation: Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making. Results: With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the 'cytotoxitiy burst' (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified 'one-biological perturbation to one-adverse outcome' model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health. %G English %2 https://cnrs.hal.science/hal-03201557/document %2 https://cnrs.hal.science/hal-03201557/file/btz570.pdf %L hal-03201557 %U https://cnrs.hal.science/hal-03201557 %~ INSERM %~ CNRS %~ UP-SCIENCES %~ BFA