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Chapitre D'ouvrage Année : 2007

Integrated Development of Glycobiologics: From Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems

Résumé

From the three major classes of biomolecules including proteins, nucleic acids and carbohydrates, the carbohydrates are, at the moment, the least exploited. The recent development of operating methods for the analysis of carbohydrates and for the synthesis of oligosaccharides supports the efforts made to investigate the roles of carbohydrates in biological phenomena. Research on carbohydrates is very active leading to discovery of new oligosaccharides and functions almost everyday as witnesses by the amount of papers published every month. The purpose of this chapter is to point out some of the functions of carbohydrates that have been identified and that may be interesting to integrate within the design of nanoparticulate drug carriers able to carry and target a drug to the diseased organs or cells. The complete control of the biodistribution of these systems which is mainly governed by their surface properties remains one of the major challenges to achieve. Among the different strategies proposed so far, it has been suggested to coat the nanoparticulate drug carriers with polysaccharides in order to mimic the surface of cells, bacteria or viruses and to confer the nanoparticles new surface properties including the biological activities of the carbohydrates. The coating of nanoparticulate drug carriers with certain types of carbohydrates may be interesting to give the nanoparticles specific recognition or signalling functions to improve their targeting specificity and efficiency. Other carbohydrates display very specific biological activities that may be interesting to combine with nanoparticulate drug carriers to create biologically active nanoparticulate systems. Many other examples will be discussed in this chapter and the benefit of the approach will be examined with the few examples of nanoparticulate drug carriers already developed on this basis.
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hal-03206197 , version 1 (23-04-2021)

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Christine Vauthier, Isabelle Bertholon, Denis Labarre. Integrated Development of Glycobiologics: From Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems. Shayne Cox Gad. Handbook of Pharmaceutical Biotechnology, Wiley, pp.125 - 160, 2007, 9780471213864. ⟨10.1002/9780470117118.ch1d⟩. ⟨hal-03206197⟩
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