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Article Dans Une Revue ChemPhysChem Année : 2021

Chemical processes involving 18-crown-6-ether in activated noncovalent complexes with protonated peptides

Résumé

These last decades, it has been widely assumed that 18-crown-6-ether (CE) plays a spectator role during the chemical processes occurring in isolated host-guest complexes between peptides or proteins and CE, after activation in mass spectrometers. Our present experimental and theoretical results challenge this hypothesis by showing that CE can abstract a proton or a protonated molecule from protonated peptides after activation by collisions in argon or electron capture/transfer. Furthermore, thanks to comparison between experimental and calculated values of collision cross-sections, we demonstrate that CE can change binding site after electron transfer. We also propose detailed mechanisms for these processes.
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Dates et versions

hal-03217252 , version 1 (04-05-2021)

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Marwa Abdelmouleh, Mathieu Lalande, Edith Nicol, Gilles Frison, Guillaume van Der Rest, et al.. Chemical processes involving 18-crown-6-ether in activated noncovalent complexes with protonated peptides. ChemPhysChem, 2021, 22 (12), pp.1243-1250. ⟨10.1002/cphc.202100075⟩. ⟨hal-03217252⟩
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