Doxorubicin-loaded metal-organic frameworks nanoparticles with engineered cyclodextrin coatings: Insights on drug location by solid state nmr spectroscopy - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Nanomaterials Année : 2021

Doxorubicin-loaded metal-organic frameworks nanoparticles with engineered cyclodextrin coatings: Insights on drug location by solid state nmr spectroscopy

Résumé

Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrincitrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including1H-1H and13C-27Al two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core–shell system. To do so,13C-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications.
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Dates et versions

hal-03218450 , version 1 (02-06-2022)

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Xue Li, Marianna Porcino, Jingwen Qiu, Doru Constantin, Charlotte Martineau-Corcos, et al.. Doxorubicin-loaded metal-organic frameworks nanoparticles with engineered cyclodextrin coatings: Insights on drug location by solid state nmr spectroscopy. Nanomaterials, 2021, 11 (4), ⟨10.3390/nano11040945⟩. ⟨hal-03218450⟩
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