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Communication Dans Un Congrès Année : 2020

Bi-directional Axial Transmission measurements is an easy to apply methodology allowing risk assessment of fracture in elderly

Johannes Schneider
Eva Kohut
  • Fonction : Auteur
Melanie Streichhahn
  • Fonction : Auteur
Rainer Wirth
  • Fonction : Auteur
Timm Westhoff
  • Fonction : Auteur
Nina Babel
  • Fonction : Auteur

Résumé

Accurate measurement of cortical bone parameters may improve fracture risk assessment and help clinicians on the best treatment strategy. The objective of this cross-sectional study was to evaluate the performance of a Bi-Directional Axial Transmission (BDAT) device used by trained operators in a clinical environment with elderly subjects. The device, positioned at one-third distal radius, provides two velocities: VFAS (first arriving signal) and VA0 (first anti-symmetrical guided mode). Moreover, two parameters are obtained from an inverse approach: Ct.Th (cortical thickness) and Ct.Po (cortical porosity). The areal bone mineral density (aBMD) was obtained using DXA at the femur and spine. Eighty seven (65 women, 22 men) from Marien Hospital and St. Anna Hospital (Herne, Germany) were included in this study. Age ranged from 41 to 95 years, while body mass index (BMI) ranged from 17 to 47 kg.m-2. Three groups were considered: 64 non-fractured patients (NF 73±13years), 23 with non-traumatic fractures (F 80±10years) including 13 patients with non-vertebral fractures (NVF 85±7years). Weak to moderate significant Spearman correlations (R ranging from 0.26 to 0.62, p<0.05) were found between ultrasound parameters and age, BMI and aBMD. VFAS, VA0 and CT.po could discriminate the subgroup NVF from the control group NF (Wilcoxon?Mann?Whitney test p<0.05), while discrimination was observed only for VFAS for the group F. We found the ratio CtPo/Ct.Th to be predictive for the fracture with odds ratio [OR] equal to 1.76 and the area under the ROC curve [AUC] equal to 0.65. Prediction of fracture was higher within the NVF group (OR=3.5; AUC=0.78), with increased sensitivity after adjustment for gender, age, and BMI (OR=2.62; AUC=0.83). The latter is comparable to femoral aBMD (OR=3.48; AUC=0.82). The fracture risk assessment by BDAT method in elderly, in a clinical setting, suggests the benefit of the affordable and transportable device for the routine use.
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Dates et versions

hal-03240260 , version 1 (29-05-2021)

Identifiants

Citer

Jean-Gabriel Minonzio, Donatien Ramiandrisoa, Johannes Schneider, Eva Kohut, Melanie Streichhahn, et al.. Bi-directional Axial Transmission measurements is an easy to apply methodology allowing risk assessment of fracture in elderly. e-Forum Acusticum 2020, Dec 2020, Lyon, France. pp.1069-1074, ⟨10.48465/fa.2020.0424⟩. ⟨hal-03240260⟩
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