%0 Journal Article %T Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma %+ Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS) %+ Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS) %+ Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA) %+ Université Claude Bernard Lyon 1 - Faculté des sciences et technologies (UCBL FST) %+ Hôpital Louis Pradel [CHU - HCL] %A Massy, E %A Rousseau, J. C. %A Gueye, M. %A Bonnelye, E. %A Brevet, M. %A Chambard, L. %A Duruisseaux, M. %A Borel, O. %A Roger, C. %A Guelminger, R. %A Pialat, J. B. %A Gineyts, E. %A Bouazza, L. %A Millet, M. %A Maury, J. M. %A Clézardin, P. %A Girard, N. %A Confavreux, Cyrille, B %< avec comité de lecture %@ 2212-1374 %J Journal of Bone Oncology %I Amsterdam : Elsevier, c2012- %V 29 %P 100364 %8 2021 %D 2021 %R 10.1016/j.jbo.2021.100364 %K bone metastasis %K periostin %K lung cancer %K serum biomarker %K survival %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] %Z Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal systemJournal articles %X More than 35% of lung adenocarcinoma patients have bone metastases at diagnosis and have a poor survival. Periostin, a carboxylated matrix protein, mediates lung cancer cell dissemination by promoting epithelial-mesenchymal transition, and is involved in bone response to mechanical stress and bone formation regulation. This suggests that periostin may be used as a biomarker to predict survival in lung cancer patients.Serum periostin was assessed at diagnosis in a prospective cohort of 133 patients with lung adenocarcinoma of all stages. Patients were divided into localized and bone metastatic groups. Both groups were matched to healthy controls. Survival analysis and Cox proportional hazards models were conducted in the total population and in bone metastatic group.The median serum periostin level was higher in bone metastatic (n = 67; median: 1752 pmol/L) than in the localized group (n = 66; 861 pmol/L; p < 0.0001). Patients with high periostin (>median) had a poorer overall survival in the whole population (33.3 weeks vs. NR; p < 0.0001) and the bone metastatic group (24.4 vs. 66.1 weeks; p < 0.001). In multivariate analysis, patients with high periostin had increased risk of death (HR = 2.09, 95%CI [1.06–4.13]; p = 0.03). This was also found in the bone metastatic group (HR = 3.62, 95%CI [1.74–7.52]; p = 0.0005). Immunohistochemistry on bone metastasis biopsies showed periostin expression in the bone matrix and nuclear and cytoplasmic staining in cancer cells.Serum periostin was an independent survival biomarker in all-stage and in bone metastatic lung adenocarcinoma patients. IHC data suggest that periostin might be induced in cancer cells in bone metastatic niche in addition to bone microenvironment expression. %G English %2 https://cnrs.hal.science/hal-03263846/document %2 https://cnrs.hal.science/hal-03263846/file/Massy%20et%20al-JBO-2021.pdf %L hal-03263846 %U https://cnrs.hal.science/hal-03263846 %~ INSERM %~ UNIV-NANTES %~ HCL %~ CNRS %~ UNIV-LYON1 %~ UNIV-ANGERS %~ CHLS %~ CRCINA %~ UDL %~ UNIV-LYON %~ NANTES-UNIVERSITE %~ UNIV-NANTES-AV2022