The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2013

The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis.

Lucas Philippe
  • Fonction : Auteur
Ghada Alsaleh-Alfarhan
  • Fonction : Auteur
  • PersonId : 948653
Seiamak Bahram
  • Fonction : Auteur
  • PersonId : 948652
Philippe Georgel
  • Fonction : Auteur
  • PersonId : 1055696

Résumé

MicroRNAs (miRNAs) are now recognized as essential regulators of gene expression in plants and animals. They potentially modulate the expression of multiple genes thereby enabling homeostatic settings in physiological conditions. Their role is also increasingly considered in many diseases in which deregulated epigenetic mechanisms induce aberrant gene expression. Work conducted in our laboratory has recently led to the identification of miRNAs essential for the control of inflammatory reactions that occur during rheumatoid arthritis (RA). In this review, we describe two such miRNAs, members of the miR-17 ∼ 92 cluster, which has been previously implicated in cancer. Based on our data and on predicted miRNA:mRNA interactions, we will extrapolate a model whereby the miR-17 ∼ 92 cluster appears as a global regulator of the Apoptosis Signal-Regulating Kinase 1 signalosome, a central actor in the inflammatory pathways activated during RA. We will also discuss the potential therapeutic outcomes emerging from this model.
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Dates et versions

hal-03273160 , version 1 (28-06-2021)

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Citer

Lucas Philippe, Ghada Alsaleh-Alfarhan, Seiamak Bahram, Sebastien Pfeffer, Philippe Georgel. The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis.. Frontiers in Immunology, 2013, 4 (Art. n°70), ⟨10.3389/fimmu.2013.00070⟩. ⟨hal-03273160⟩

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