Identification of sex‐specific biomarkers predicting new‐onset heart failure - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue ESC Heart Failure Année : 2021

Identification of sex‐specific biomarkers predicting new‐onset heart failure

1 MUMC - Maastricht University Medical Centre
2 CARIM - Cardiovascular Research Institute Maastricht
3 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
4 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
5 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
6 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
7 LSHTM - London School of Hygiene and Tropical Medicine
8 TATAA Biocenter AB
9 Casa di Cura Quisisana
10 University of Hull [United Kingdom]
11 Castle Hill Hospital
12 Institute of Cardiovascular and Medical Sciences [Glasgow]
13 CIBERCV, Carlos III Institute of Health
14 IdiSNA - Instituto de Investigacion Sanitaria de Navarra
15 UNAV - Universidad de Navarra [Pamplona]
16 Clínica Universidad de Navarra [Pamplona]
17 Netherlands Heart Institute
18 LUMC - Leiden University Medical Center
19 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
20 Fraunhofer ITEM - Fraunhofer Institute for Toxicology and Experimental Medicine
21 Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School
22 Hôpital Lariboisière-Fernand-Widal [APHP]
23 UPCité - Université Paris Cité
24 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
25 UMCG - University Medical Center Groningen [Groningen]
26 Non-Profit Research Institute Alliance for the Promotion of Preventive Medicine
27 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
28 Institute of Health and Wellbeing
29 University of Glasgow
30 Royal Brompton and Harefield NHS Foundation Trust
31 NHLI - National Heart and Lung Institute [London]

Résumé

Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results: A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH-ABC, & PROSPER), follow-up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O-link. To look for sex differences for new onset HF, we adjusted for cohort, age, and baseline clinical parameters. At baseline, women had a biomarker profile reflecting activated metabolism and immune responses. However, none of the biomarkers had a significant interaction with sex in predicting new onset HF, but four biomarkers had a trend towards sex-specificity (P < 0.013). E-selectin and interleukin 1 receptor antagonist were more female-specific, whereas IL17A and CHIT1 tended to be male sex-specific for incident HF. Conclusions: The majority of biomarkers associated with incident HF did not significantly differ between women and men, despite clear differences in biomarkers at baseline.
Fichier principal
Vignette du fichier
ehf2.13476.pdf (343.18 Ko) Télécharger le fichier
ehf2_13476-sup-0001-table_s1.pdf (472.9 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03273973 , version 1 (29-06-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Anne Raafs, Job Verdonschot, João Pedro Ferreira, Ping Wang, Timothy Collier, et al.. Identification of sex‐specific biomarkers predicting new‐onset heart failure. ESC Heart Failure, 2021, ⟨10.1002/ehf2.13476⟩. ⟨hal-03273973⟩
81 Consultations
265 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More