%0 Journal Article %T Incidence of the melting-degradation process of vitamin C on the determination of the phase diagram with acetaminophen enhanced by high performance liquid chromatography tools %+ Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)) %A Corvis, Yohann %A Menet, Marie-Claude %A Espeau, Philippe %< avec comité de lecture %@ 1144-0546 %J New Journal of Chemistry %I Royal Society of Chemistry %V 39 %N 3 %P 1938-1942 %8 2015 %D 2015 %R 10.1039/c4nj01766h %K ASCORBIC-ACID %K PARACETAMOL %Z Chemical Sciences/Analytical chemistry %Z Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]Journal articles %X Compounds that degrade upon melting, such as vitamin C, are not convenient for temperature-composition phase diagram survey. To bypass such a disadvantage, faster scan rates may be used to heat the samples. However, in that case, the thermodynamic solid-liquid equilibrium cannot be reached as the present study demonstrates regarding the vitamin C-acetaminophen phase diagram determination. In this work, high performance liquid chromatography has therefore been used as a complementary tool with differential scanning calorimetry to determine the appropriate liquidus point for various mole fractions of vitamin C-acetaminophen. Because a classical thermodynamic approach is not sufficient for such a study, the analytical experiments that we have conducted provide useful data, allowing us to determine the non-degraded vitamin C quantity in the vitamin C-acetaminophen mixtures treated at a given temperature and annealing time. %G English %L hal-03290587 %U https://cnrs.hal.science/hal-03290587 %~ UNIV-PARIS5 %~ ENSCP %~ CNRS %~ ENSC-PARIS %~ PARISTECH %~ INC-CNRS %~ PSL %~ UNIV-PARIS %~ UP-SANTE %~ ENSCP-PSL %~ UTCBS %~ TEST2-HALCNRS