Mechanical instabilities of aorta drive blood stem cell production: a live study - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Cellular and Molecular Life Sciences Année : 2020

Mechanical instabilities of aorta drive blood stem cell production: a live study

Résumé

During embryogenesis of all vertebrates, haematopoietic stem/progenitor cells (HSPCs) extrude from the aorta by a complex process named endothelial-to-haematopoietic transition (EHT). HSPCs will then colonize haematopoietic organs allowing haematopoiesis throughout adult life. The mechanism underlying EHT including the role of each aortic endothelial cell (EC) within the global aorta dynamics remains unknown. In the present study, we show for the first time that EHT involves the remodelling of individual cells within a collective migration of ECs which is tightly orchestrated, resulting in HSPCs extrusion in the sub-aortic space without compromising aorta integrity. By performing a cross-disciplinary study which combines high-resolution 4D imaging and theoretical analysis based on the concepts of classical mechanics, we propose that this complex developmental process is dependent on mechanical instabilities of the aorta preparing and facilitating the extrusion of HSPCs.

Dates et versions

hal-03291847 , version 1 (19-07-2021)

Licence

Paternité

Identifiants

Citer

Nausicaa Poullet, Ivan Golushko, Vladimir Lorman, Jana Travnickova, Charlotte Bureau, et al.. Mechanical instabilities of aorta drive blood stem cell production: a live study. Cellular and Molecular Life Sciences, 2020, 77 (17), pp.3453-3464. ⟨10.1007/s00018-019-03372-2⟩. ⟨hal-03291847⟩
60 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More