RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Development (Cambridge, England) Année : 2001

RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

H Chiba
  • Fonction : Auteur
X Warot
  • Fonction : Auteur
N Messaddeq
  • Fonction : Auteur
C Gérard
  • Fonction : Auteur
P Chambon
  • Fonction : Auteur
D Metzger
  • Fonction : Auteur

Résumé

RXR-alpha is the most abundant of the three retinoid X receptors (RXRs) in the epidermis. In this study, we have used Cre-mediated recombination to selectively disrupt the mouse gene for RXR-alpha in epidermal and hair follicle keratinocytes. We show that RXR-alpha is apparently dispensable for prenatal epidermal development, while it is involved in postnatal skin maturation. After the first hair pelage, mutant mice develop a progressive alopecia, histologically characterised by the destruction of hair follicle architecture and the formation of utriculi and dermal cysts in adult mice. Our results demonstrate that RXR-alpha plays a key role in anagen initiation during the hair follicle cycle. In addition, RXR-alpha ablation results in epidermal interfollicular hyperplasia with keratinocyte hyperproliferation and aberrant terminal differentiation, accompanied by an inflammatory reaction of the skin. Our data not only provide genetic evidence that RXR-alpha/VDR heterodimers play a major role in controlling hair cycling, but also suggest that additional signalling pathways mediated by RXR-alpha heterodimerised with other nuclear receptors are involved in postnatal hair follicle growth, and homeostasis of proliferation/differentiation of epidermal keratinocytes and of the skin's immune system.
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Dates et versions

hal-03311495 , version 1 (31-07-2021)

Identifiants

  • HAL Id : hal-03311495 , version 1
  • PUBMED : 11171393

Citer

M Li, H Chiba, X Warot, N Messaddeq, C Gérard, et al.. RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.. Development (Cambridge, England), 2001, 128 (5), pp.675-88. ⟨hal-03311495⟩
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