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Article Dans Une Revue The Journal of Frailty & Aging Année : 2021

Healthy Aging Biomarkers: The INSPIRE's Contribution

Isabelle Ader
Pierre Payoux
Julien Yves Rolland
Nathalie Vergnolle
  • Fonction : Auteur
  • PersonId : 1203198
Bruno Vellas

Résumé

The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.
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hal-03320578 , version 1 (16-08-2021)

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Isabelle Ader, Luc Penicaud, Sandrine Andrieu, J.R. Beard, Noélie Davezac, et al.. Healthy Aging Biomarkers: The INSPIRE's Contribution. The Journal of Frailty & Aging, 2021, ⟨10.14283/jfa.2021.15⟩. ⟨hal-03320578⟩
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