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Article Dans Une Revue Journal of The American Society for Mass Spectrometry Année : 2020

Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry

Résumé

When electrosprayed from native solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial structure in solution. Here we show the limits of using force field molecular dynamics to interpret the gas-phase structures of nucleic acid complexes in the gas phase, and we suggest that higher-level calculation levels should be used in the future.
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Dates et versions

hal-03321844 , version 1 (18-08-2021)

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Josephine Abi-Ghanem, Clémence Rabin, Massimiliano Porrini, Frédéric Rosu, Valérie Gabelica. Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry. Journal of The American Society for Mass Spectrometry, 2020, 31 (10), pp.2035-2043. ⟨10.1021/jasms.0c00060⟩. ⟨hal-03321844⟩
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