Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata
Résumé
A new modified geranylated flavonoid, 6-(8″-hydroxy-3″,8″-trimethyloct-2″-enyl)-kaempferol (1), along with seventeen known compounds (2-18) were isolated from the fruits of Macaranga denticulata. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, and 2D-NMR. Compounds 1-13 were evaluated for their cytotoxicity against seven cancer cell lines MCF-7, HepG2, Hep3B, Lu-1, Hela, KB, A549. The new geranylated flavonoid 1 showed a moderate cytotoxic activity against the A549 cell line with IC50 value of 16.0 µM. Compound 9 showed the highest cytotoxic activities against KB, HepG2, Lu-1, and MCF7 cell lines with IC50 values of 0.6, 0.8, 1.3, and 1.2 µM, respectively.
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