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Article Dans Une Revue Natural Product Research Année : 2021

Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata

Résumé

A new modified geranylated flavonoid, 6-(8″-hydroxy-3″,8″-trimethyloct-2″-enyl)-kaempferol (1), along with seventeen known compounds (2-18) were isolated from the fruits of Macaranga denticulata. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, and 2D-NMR. Compounds 1-13 were evaluated for their cytotoxicity against seven cancer cell lines MCF-7, HepG2, Hep3B, Lu-1, Hela, KB, A549. The new geranylated flavonoid 1 showed a moderate cytotoxic activity against the A549 cell line with IC50 value of 16.0 µM. Compound 9 showed the highest cytotoxic activities against KB, HepG2, Lu-1, and MCF7 cell lines with IC50 values of 0.6, 0.8, 1.3, and 1.2 µM, respectively.
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Dates et versions

hal-03354034 , version 1 (27-09-2021)

Identifiants

Citer

Tran Nguyen Vu Le, Bich Ngan Truong, Thi Phuong Le, Marc Litaudon, Dang Tran Thach, et al.. Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata. Natural Product Research, 2021, 35 (11), pp.1861-1868. ⟨10.1080/14786419.2019.1639175⟩. ⟨hal-03354034⟩
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