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Article Dans Une Revue Polymer Chemistry Année : 2021

Synthesis and sequencing of informational poly(amino phosphodiester)s

Olivier Felix
Isaure Carvin-Sergent
Laurence Charles
Jean-François Lutz

Résumé

Sequenced-defined poly(amino phosphodiester)s containing mainchain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.

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Polymères
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Dates et versions

hal-03367205 , version 1 (06-10-2021)

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Ian Roszak, Laurence Oswald, Abdelaziz Al Ouahabi, Annabelle Bertin, Eline Laurent, et al.. Synthesis and sequencing of informational poly(amino phosphodiester)s. Polymer Chemistry, 2021, 12 (37), pp.5279-5282. ⟨10.1039/D1PY01052B⟩. ⟨hal-03367205⟩
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