Synthesis and sequencing of informational poly(amino phosphodiester)s
Résumé
Sequenced-defined poly(amino phosphodiester)s containing mainchain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.
Domaines
Polymères
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