Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Extracellular Vesicles Année : 2020

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus

Olivier Schwartz

Résumé

SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys for SARS-CoV-2 S protein-containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.

Domaines

Immunologie
Fichier principal
Vignette du fichier
jev2.12050(1).pdf (1.01 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03367539 , version 1 (04-11-2020)
hal-03367539 , version 2 (07-10-2021)

Licence

Paternité

Identifiants

Citer

Federico Cocozza, Nathalie Névo, Ester Piovesana, Xavier Lahaye, Julian Buchrieser, et al.. Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus. Journal of Extracellular Vesicles, 2020, 10 (2), pp.e12050. ⟨10.1002/jev2.12050⟩. ⟨hal-03367539v2⟩
193 Consultations
132 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More