%0 Journal Article %T Reactive astrocyte nomenclature, definitions, and future directions %+ Service MIRCEN (MIRCEN) %+ Universitat Autònoma de Barcelona (UAB) %+ ICREA Infection Biology Laboratory (Department of Experimental and Health Sciences) %+ University of Cambridge [UK] (CAM) %+ National Institute for Occupational Safety and Health [Morgantown, WV, USA] (NIOSH) %+ German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) %+ University Hospital Bonn %+ Massachusetts General Hospital [Charlestown, MA, États-Unis] %+ University of Bonn %+ Université de Lausanne = University of Lausanne (UNIL) %+ Italian National Research Council [Padova, Italy] %+ Università degli Studi di Padova = University of Padua (Unipd) %+ Heidelberg University %+ The Salk Institute for Biological Studies %+ University of Minnesota [MN, USA] %+ Institut Pasteur de Montevideo %+ Tel Aviv University (TAU) %+ Johns Hopkins University School of Medicine [Baltimore] %+ University of Portsmouth %+ Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven) %+ Centre interdisciplinaire de recherche en biologie (CIRB) %+ Trinity College Dublin %+ Baylor College of Medicine (BCM) %+ University College of London [London] (UCL) %+ University of Edinburgh %+ San Raffaele Scientific Institute %+ Vollum Institute %+ National Children's Hospital %+ Columbia University [New York] %+ University of Rochester Medical Center (URMC) %+ University of Copenhagen = Københavns Universitet (UCPH) %+ Ludwig Maximilians Universitaet %+ SYNERGY, Excellence Cluster of Systems Neurology %+ Universidad de Málaga [Málaga] = University of Málaga [Málaga] %+ Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) %+ Tufts University School of Medicine [Boston] %+ University of Freiburg [Freiburg] %+ Utrecht University [Utrecht] %+ Nihon University School of Medicine [Tokyo, Japan] %+ Max Delbrück Center for Molecular Medicine [Berlin] (MDC) %+ David Geffen School of Medicine [Los Angeles] %+ Yamanashi University %+ Institute for Basic Science [Daejeon] (IBS) %+ New York University School of Medicine (NYU) %+ University of British Columbia (UBC) %+ King Abdullah University of Science and Technology (KAUST) %+ University of Wisconsin-Madison %+ Oregon Health and Science University [Portland] (OHSU) %+ University of California [San Francisco] (UC San Francisco) %+ McGill University Health Center [Montreal] (MUHC) %+ University of Kentucky (UK) %+ Kyushu University %+ Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB) %+ University of Minho [Braga] %+ ICVS/3B's—PT Government Associate Laboratory [Braga, Portugal] %+ Polytechnic Institute of Cávado and Ave %+ University of Alabama at Birmingham [ Birmingham] (UAB) %+ University of Gothenburg (GU) %+ Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT) %+ Cajal Institute %+ King‘s College London %+ Institut des Neurosciences Cellulaires et Intégratives (INCI) %+ Brigham & Women’s Hospital [Boston] (BWH) %+ Third Rock Ventures %+ Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] %+ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) %+ Sechenov First Moscow State Medical University %+ Ludwig Maximilian University [Munich] (LMU) %+ Institute for Stem Cell Research [Neuherberg] %+ Universidad de Sevilla / University of Sevilla %+ Georgia Institute of Technology [Atlanta] %+ The University of Texas Health Science Center at Houston (UTHealth) %+ School of Medicine [Univ California San Diego] (UC San Diego) %+ Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS) %+ University of Ljubljana %+ University of California [Los Angeles] (UCLA) %+ University of Manchester [Manchester] %+ Ikerbasque - Basque Foundation for Science %A Escartin, Carole %A Galea, Elena %A Lakatos, András %A O’callaghan, James %A Petzold, Gabor %A Serrano-Pozo, Alberto %A Steinhäuser, Christian %A Volterra, Andrea %A Carmignoto, Giorgio %A Agarwal, Amit %A Allen, Nicola %A Araque, Alfonso %A Barbeito, Luis %A Barzilai, Ari %A Bergles, Dwight %A Bonvento, Gilles %A Butt, Arthur %A Chen, Wei-Ting %A Cohen-Salmon, Martine %A Cunningham, Colm %A Deneen, Benjamin %A de Strooper, Bart %A Díaz-Castro, Blanca %A Farina, Cinthia %A Freeman, Marc %A Gallo, Vittorio %A Goldman, James %A Goldman, Steven %A Götz, Magdalena %A Gutiérrez, Antonia %A Haydon, Philip %A Heiland, Dieter %A Hol, Elly %A Holt, Matthew %A Iino, Masamitsu %A Kastanenka, Ksenia %A Kettenmann, Helmut %A Khakh, Baljit %A Koizumi, Schuichi %A Lee, C. Justin %A Liddelow, Shane %A Macvicar, Brian %A Magistretti, Pierre %A Messing, Albee %A Mishra, Anusha %A Molofsky, Anna %A Murai, Keith %A Norris, Christopher %A Okada, Seiji %A Oliet, Stéphane %A Oliveira, João %A Panatier, Aude %A Parpura, Vladimir %A Pekna, Marcela %A Pekny, Milos %A Pellerin, Luc %A Perea, Gertrudis %A Pérez-Nievas, Beatriz %A Pfrieger, Frank %A Poskanzer, Kira %A Quintana, Francisco %A Ransohoff, Richard %A Riquelme-Perez, Miriam %A Robel, Stefanie %A Rose, Christine %A Rothstein, Jeffrey %A Rouach, Nathalie %A Rowitch, David %A Semyanov, Alexey %A Sirko, Swetlana %A Sontheimer, Harald %A Swanson, Raymond %A Vitorica, Javier %A Wanner, Ina-Beate %A Wood, Levi %A Wu, Jiaqian %A Zheng, Binhai %A Zimmer, Eduardo %A Zorec, Robert %A Sofroniew, Michael %A Verkhratsky, Alexei %< avec comité de lecture %@ 1097-6256 %J Nature Neuroscience %I Nature Publishing Group %V 24 %N 3 %P 312-325 %8 2021-03 %D 2021 %R 10.1038/s41593-020-00783-4 %Z Life Sciences [q-bio]Journal articles %X Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions. %G English %L hal-03372664 %U https://cnrs.hal.science/hal-03372664 %~ CEA %~ RIIP %~ ESPCI %~ CNRS %~ CDF %~ UNIV-POITIERS %~ UNIV-STRASBG %~ RIIP_MONTEVIDEO %~ PARISTECH %~ CEA-UPSAY %~ PSL %~ UNIV-PARIS-SACLAY %~ IRTOMIT %~ JACOB %~ CEA-DRF %~ SITE-ALSACE %~ MIRCEN %~ TEST-HALCNRS %~ ENS-PSL %~ ESPCI-PSL %~ CDF-PSL %~ UNIVERSITE-PARIS-SACLAY %~ MAGENDIE