α-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population - CNRS - Centre national de la recherche scientifique Access content directly
Journal Articles Stem Cell Reviews and Reports Year : 2021

α-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population

Darija Loncaric
  • Function : Author
Laura Rodriguez
  • Function : Author
Christelle Debeissat
  • Function : Author
Nicolas Touya
  • Function : Author
Veronique Labat
  • Function : Author
Arnaud Villacreces
Jean-Max Pasquet
  • Function : Author
Philippe Brunet de La Grange
  • Function : Author
Marija Vlaski-Lafarge
  • Function : Author
Sonja Pavlovic
  • Function : Author
Zoran Ivanovic
  • Function : Author
  • PersonId : 874773

Abstract

We present here the data showing, in standard cultures exposed to atmospheric O 2 concentration, that alpha-tocopherol acetate (α-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. α-TOA decreases the O 2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1α was decreased in presence of α-TOA. This is in line with a moderate enhancement of mtROS upon α-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1α which might-if it were active-be related to the maintenance of stemness. It should be stressed that α-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated.
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hal-03376630 , version 1 (25-10-2021)

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Darija Loncaric, Laura Rodriguez, Christelle Debeissat, Nicolas Touya, Veronique Labat, et al.. α-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. Stem Cell Reviews and Reports, 2021, 17 (4), pp.1390-1405. ⟨10.1007/s12015-020-10111-9⟩. ⟨hal-03376630⟩

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