Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2021

Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma

Noémie Robil
  • Fonction : Auteur
Juliette Hamroune
Gwennhael Autret
Jérémy Augustin
Laura Fouassier
Chantal Housset
Patrick Soussan

Résumé

Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models of cholangitis challenged with syngeneic CCA, PBC (but not PSC) reduced the frequency of CCA development and delayed tumor growth kinetics. This PBC-related effect appeared specific to CCA as it was not observed against other cancers, including hepatocellular carcinoma. The protective effect of PBC was relying on type 1 and type 2 T cell responses and, to a lesser extent, on B cells. Single-cell TCR/RNA sequencing revealed the existence of TCR clonotypes shared between the liver and CCA tumor of a PBC host. Altogether, these results evidence a mechanistic overlapping between autoimmunity and cancer immunosurveillance in the biliary tract.

Domaines

Cancer
Fichier principal
Vignette du fichier
jem_20200853.pdf (8.3 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03378827 , version 1 (07-03-2024)

Identifiants

Citer

Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour, Gautier Stoll, et al.. Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma. Journal of Experimental Medicine, 2021, 218 (10), pp.1-33. ⟨10.1084/jem.20200853⟩. ⟨hal-03378827⟩
120 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More