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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2022

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis

Résumé

SignificanceThe proteasome is responsible for the homeostasis of intracellular proteins. Here, we describe structural and functional aspects of a poorly characterized proteasome subtype found exclusively in germ cells. The spermatoproteasome was recently shown to be essential for spermatogenesis, a process requiring intense proteolysis. It differs from the constitutive proteasome by only one subunit, α4s, a subunit that replaces its α4 ubiquitous counterpart. In this work, we show how the shift from α4 to α4s regulates proteasome composition, dynamics, interactome, and activity. We reveal a regulation process more complex than previously suggested, which provides the basis for structural and functional studies of the spermatoproteasome.
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hal-03660083 , version 1 (22-10-2021)
hal-03660083 , version 2 (01-06-2023)

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Dušan Živković, Angelique Sanchez Dafun, Thomas Menneteau, Adrien Schahl, Sandrine Lise, et al.. Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (15), pp.e2116826119. ⟨10.1073/pnas.2116826119⟩. ⟨hal-03660083v2⟩
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