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Article Dans Une Revue Pharmaceutics Année : 2021

Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma

Eric Savier
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Lorena Simon-Gracia
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Frederic Charlotte
Tambet Teesalu

Résumé

Background: The interfering peptides that block protein–protein interactions have been receiving increasing attention as potential therapeutic tools. Methods: We measured the internalization and biological effect of four bi-functional tumor-penetrating and interfering peptides into primary hepatocytes isolated from three non-malignant and 11 hepatocellular carcinomas. Results: These peptides are internalized in malignant hepatocytes but not in non-malignant cells. Furthermore, the degree of peptide internalization correlated with receptor expression level and tumor aggressiveness levels. Importantly, penetration of the peptides iRGD-IP, LinTT1-IP, TT1-IP, and RPARPAR-IP induced apoptosis of the malignant hepatocytes without effect on non-malignant cells. Conclusion: Receptor expression levels correlated with the level of peptide internalization and aggressiveness of the tumor. This study highlights the potential to exploit the expression of tumor-penetrating peptide receptors as a predictive marker of liver tumor aggressiveness. These bi-functional peptides could be developed for personalized tumor treatment.
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Dates et versions

hal-03405487 , version 1 (27-10-2021)

Identifiants

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Eric Savier, Lorena Simon-Gracia, Frederic Charlotte, Pierre Tuffery, Tambet Teesalu, et al.. Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma. Pharmaceutics, 2021, 13 (10), pp.1631. ⟨10.3390/pharmaceutics13101631⟩. ⟨hal-03405487⟩
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