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Article Dans Une Revue Chemical Communications Année : 2011

alpha-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors

Ethan Goddard-Borger
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Raphaël Carapito
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Vincent Phalip
Robert Stick
  • Fonction : Auteur
Annabelle Varrot

Résumé

As part of continued efforts to understand the mechanisms of 1,5-alpha-L-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.
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hal-03408190 , version 1 (28-10-2021)

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Ethan Goddard-Borger, Raphaël Carapito, Jean-Marc Jeltsch, Vincent Phalip, Robert Stick, et al.. alpha-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors. Chemical Communications, 2011, 47 (34), pp.9684-9686. ⟨10.1039/c1cc13675e⟩. ⟨hal-03408190⟩
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