Rheumatoid Arthritis in the View of Osteoimmunology - Archive ouverte HAL Access content directly
Journal Articles Biomolecules Year : 2020

Rheumatoid Arthritis in the View of Osteoimmunology

Mélanie Auréal
Irma Machuca‐gayet
Fabienne Coury
  • Function : Author
  • PersonId : 1064710

Abstract

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone erosions, both highlighting the immense reciprocal relationship between the immune and bone systems, designed osteoimmunology two decades ago. Osteoclast-mediated resorption at the interface between synovium and bone is responsible for the articular bone erosions. The main triggers of this local bone resorption are autoantibodies directed against citrullinated proteins, as well as pro-inflammatory cytokines and the receptor activator of nuclear factor-κB ligand, that regulate both the formation and activity of the osteoclast, as well as immune cell functions. In addition, local bone loss is due to the suppression of osteoblast-mediated bone formation and repair by inflammatory cytokines. Similarly, inflammation affects systemic bone remodeling in rheumatoid arthritis with the net increase in bone resorption, leading to systemic osteoporosis. This review summarizes the substantial progress that has been made in understanding the pathophysiology of systemic and local bone loss in rheumatoid arthritis.
Fichier principal
Vignette du fichier
biomolecules-11-00048 .pdf (1.96 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03414614 , version 1 (04-11-2021)

Identifiers

Cite

Mélanie Auréal, Irma Machuca‐gayet, Fabienne Coury. Rheumatoid Arthritis in the View of Osteoimmunology. Biomolecules, 2020, 11, ⟨10.3390/biom11010048⟩. ⟨hal-03414614⟩

Collections

CNRS
985 View
16 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More