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Article Dans Une Revue Nature Communications Année : 2021

DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans

Jieyu Shen
Graham L Banes
Zhihua Zhang
  • Fonction : Auteur
Jianmin Wu
Xun Huang
Hua Chen
Siqin Ge
  • Fonction : Auteur
Yong E Zhang
  • Fonction : Auteur
  • PersonId : 1139054

Résumé

Despite long being considered as "junk", transposable elements (TEs) are now accepted as catalysts of evolution. One example is Mutator-like elements (MULEs, one type of terminal inverted repeat DNA TEs, or TIR TEs) capturing sequences as Pack-MULEs in plants. However, their origination mechanism remains perplexing, and whether TIR TEs mediate duplication in animals is almost unexplored. Here we identify 370 Pack-TIRs in 100 animal reference genomes and one Pack-TIR (Ssk-FB4) family in fly populations. We find that singlecopy Pack-TIRs are mostly generated via transposition-independent gap filling, and multicopy Pack-TIRs are likely generated by transposition after replication fork switching. We show that a proportion of Pack-TIRs are transcribed and often form chimeras with hosts. We also find that Ssk-FB4s represent a young protein family, as supported by proteomics and signatures of positive selection. Thus, TIR TEs catalyze new gene structures and new genes in animals via both transposition-independent and-dependent mechanisms.
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Dates et versions

hal-03436190 , version 1 (19-11-2021)

Identifiants

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Shengjun Tan, Huijing Ma, Jinbo Wang, Man Wang, Mengxia Wang, et al.. DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans. Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24585-9⟩. ⟨hal-03436190⟩
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