Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2021

Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties

Résumé

Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro and in vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through near-infrared optical imaging in cells and in mice. They display anti-proliferative properties in micromolar range against human and murine cancer cell lines (4T1, MDA-MB-231, CT26, and SW480). Moreover, the injection of the most promising theranostic agent in CT26 tumor-bearing BALB/c mice induced a significant anti-cancer activity.

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Chimie
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Dates et versions

hal-03436249 , version 1 (09-05-2023)

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Paternité - Pas d'utilisation commerciale

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Citer

Robin Lescure, Malorie Privat, Jacques Pliquett, Aurélie Massot, Océane Baffroy, et al.. Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties. European Journal of Medicinal Chemistry, 2021, 220 (4), pp.113483. ⟨10.1016/j.ejmech.2021.113483⟩. ⟨hal-03436249⟩
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