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Article Dans Une Revue Journal of Tissue Engineering and Regenerative Medicine Année : 2021

Post-decellularization techniques ameliorate cartilage decellularization process for tissue engineering applications

Résumé

Due to the current lack of innovative and effective therapeutic approaches, tissue engineering (TE) has attracted much attention during the last decades providing new hopes for the treatment of several degenerative disorders. Tissue engineering is a complex procedure, which includes processes of decellularization and recellularization of biological tissues or functionalization of artificial scaffolds by active cells. In this review, we have first discussed those conventional steps, which have led to great advancements during the last several years. Moreover, we have paid special attention to the new methods of post-decellularization that can significantly ameliorate the efficiency of decellularized cartilage extracellular matrix (ECM) for the treatment of osteoarthritis (OA). We propose a series of post-decellularization procedures to overcome the current shortcomings such as low mechanical strength and poor bioactivity to improve decellularized ECM scaffold towards much more efficient and higher integration.

Dates et versions

hal-03439407 , version 1 (22-11-2021)

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Citer

Mahsa Nouri Barkestani, Sina Naserian, Georges Uzan, Sara Shamdani. Post-decellularization techniques ameliorate cartilage decellularization process for tissue engineering applications. Journal of Tissue Engineering and Regenerative Medicine, 2021, 12 (8), pp.204173142098356. ⟨10.1177/2041731420983562⟩. ⟨hal-03439407⟩
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