A versatile and straightforward process to turn plastics into antibacterial materials - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Polymer Chemistry Année : 2022

A versatile and straightforward process to turn plastics into antibacterial materials

Marc Maresca
Didier Gigmes
Ariane Deniset-Besseau
Yohann Guillaneuf
Catherine Lefay

Résumé

We demonstrate that antibacterial activity can be conferred to common plastic materials using amphiphilic cationic methacrylate-based block copolymers, specifically quaternized poly(butyl methacrylate)-b-poly(N,N-dimethyl-aminoethyl methacrylate) (PBMA-b-PDMAEMA) with 64 mol% of DMAEMA and Mn close to 20 000 g mol−1. With 0.5–2 wt% of these copolymers simply dispersed in the given matrix by extrusion, the modified materials prove to be active against E. coli, S. aureus, Listeria monocytogenes and enterohemorrhagic E. coli without toxicity against two cell lines, HaCaT and L929 fibroblasts, while keeping the mechanical properties of the materials intact. In addition, the study of the mechanism of action shows that the antibacterial materials target the bacterial membrane, which is expected to avoid antibacterial resistance. Our protocol is a cost-effective solution to generate antibacterial materials for several applications, including packaging or medical devices, without modification of the production process.
Fichier principal
Vignette du fichier
2021_Polymer Chemistry.pdf (3.35 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03465949 , version 1 (04-12-2021)

Licence

Paternité

Identifiants

Citer

Slim Hadiouch, Marc Maresca, Didier Gigmes, Guilherme Machado, Aurelien Maurel-Pantel, et al.. A versatile and straightforward process to turn plastics into antibacterial materials. Polymer Chemistry, 2022, ⟨10.1039/D1PY01344K⟩. ⟨hal-03465949⟩
65 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More