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Article Dans Une Revue Pflügers Archiv European Journal of Physiology Année : 2018

Chromogranins: from discovery to current times

Karen B. Helle
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Marie-Hélène Metz-Boutigue
  • Fonction : Auteur
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Maria Carmela Cerra
  • Fonction : Auteur
Tommaso Angelone
  • Fonction : Auteur

Résumé

The discovery in 1953 of the chromaffin granules as co-storage of catecholamines and ATP was soon followed by identification of a range of uniquely acidic proteins making up the isotonic vesicular storage complex within elements of the diffuse sympathoadrenal system. In the mid-1960s, the enzymatically inactive, major core protein, chromogranin A was shown to be exocytotically discharged from the stimulated adrenal gland in parallel with the co-stored catecholamines and ATP. A prohormone concept was introduced when one of the main storage proteins collectively named granins was identified as the insulin release inhibitory polypeptide pancreastatin. A wide range of granin-derived biologically active peptides have subsequently been identified. Both chromogranin A and chromogranin B give rise to antimicrobial peptides of relevance for combat of pathogens. While two of the chromogranin A-derived peptides, vasostatin-I and pancreastatin, are involved in modulation of calcium and glucose homeostasis, respectively, vasostatin-I and catestatin are important modulators of endothelial permeability, angiogenesis, myocardial contractility, and innate immunity. A physiological role is now evident for the full-length chromogranin A and vasostatin-I as circulating stabilizers of endothelial integrity and in protection against myocardial injury. The high circulating levels of chromogranin A and its fragments in patients suffering from various inflammatory diseases have emerged as challenges for future research and clinical applications. Keywords: Catestatin; Chromogranin A; Chromogranin B; Inflammatory diseases; Physiological roles; Vasostatin-I.

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Autre [q-bio.OT]
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Dates et versions

hal-03471696 , version 1 (08-12-2021)

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Citer

Karen B. Helle, Marie-Hélène Metz-Boutigue, Maria Carmela Cerra, Tommaso Angelone. Chromogranins: from discovery to current times. Pflügers Archiv European Journal of Physiology, 2018, 470 (1), pp.143-154. ⟨10.1007/s00424-017-2027-6⟩. ⟨hal-03471696⟩
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