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Article Dans Une Revue Scientific Reports Année : 2016

Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.

Noria Segueni
  • Fonction : Auteur
Sulayman Benmerzoug
  • Fonction : Auteur
Stéphanie Rose
  • Fonction : Auteur
Amandine Gauthier
  • Fonction : Auteur
Marie-Laure Bourigault
  • Fonction : Auteur
Flora Reverchon
  • Fonction : Auteur
Amandine Philippeau
  • Fonction : Auteur
François Erard
  • Fonction : Auteur
Hélène Bouscayrol
  • Fonction : Auteur
Thierry Wachter
  • Fonction : Auteur
Irène Garcia
  • Fonction : Auteur
George Kollias
Muazzam Jacobs
  • Fonction : Auteur
Bernhard Ryffel
  • Fonction : Auteur
  • PersonId : 841831
Valérie Quesniaux

Résumé

TNF is crucial for controlling Mycobacterium tuberculosis infection and understanding how will help immunomodulating the host response. Here we assessed the contribution of TNFR1 pathway from innate myeloid versus T cells. We first established the prominent role of TNFR1 in haematopoietic cells for controlling M. tuberculosis in TNFR1 KO chimera mice. Further, absence of TNFR1 specifically on myeloid cells (M-TNFR1 KO) recapitulated the uncontrolled M. tuberculosis infection seen in fully TNFR1 deficient mice, with increased bacterial burden, exacerbated lung inflammation, and rapid death. Pulmonary IL-12p40 over-expression was attributed to a prominent CD11b(+) Gr1(high) cell population in infected M-TNFR1 KO mice. By contrast, absence of TNFR1 on T-cells did not compromise the control of M. tuberculosis infection over 6-months. Thus, the protective TNF/TNFR1 pathway essential for controlling primary M. tuberculosis infection depends on innate macrophage and neutrophil myeloid cells, while TNFR1 pathway in T cells is dispensable.

Domaines

Immunité innée

Dates et versions

hal-03477386 , version 1 (13-12-2021)

Identifiants

Citer

Noria Segueni, Sulayman Benmerzoug, Stéphanie Rose, Amandine Gauthier, Marie-Laure Bourigault, et al.. Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.. Scientific Reports, 2016, 6 (1), ⟨10.1038/srep22454⟩. ⟨hal-03477386⟩

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