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Article Dans Une Revue Molecules Année : 2021

Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems

Xue Li
Ruxandra Gref
Charlotte Martineau-Corcos

Résumé

In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.

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Matériaux
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Dates et versions

hal-03503491 , version 1 (02-02-2024)

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Paternité

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Marianna Porcino, Xue Li, Ruxandra Gref, Charlotte Martineau-Corcos. Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems. Molecules, 2021, 26 (14), pp.4142. ⟨10.3390/molecules26144142⟩. ⟨hal-03503491⟩
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