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Poster De Conférence Année : 2021

A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS

Résumé

Identifying and characterizing Extracellular vesicles (EVs) in biofluids could lead to unprecedented diagnosis/prognosis assays for a wide set of pathologies. Owe to their complexity in size, origin, membrane markers, there is currently no ideal technology available yet to sort, to quantify and characterize cell-derived microvesicles, and fully relate their structure and functions which have high potential in clinical diagnostics and early treatment of life threatening diseases such as cancer, cardio vascular diseases…. Lab-on-chip for EVs size-based separation Chip EVs capture Sample EVs characterization (AFM imaging, mass spectrometry) APPROACH We propose to couple a microfluidic device (LOC) enabling to separate particles from a complex sample to a device allowing the capture of particles on specific spots and their analysis. These methods allow obtaining important information on a chip about nanoscale vesicles in terms of size, membrane markers expression, and structure-function properties.
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Dates et versions

hal-03514467 , version 1 (06-01-2022)

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  • HAL Id : hal-03514467 , version 1

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Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Celine Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Oct 2021, Palm Spring, United States. , MicroTAS 2021, 2021, The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. ⟨hal-03514467⟩
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