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Chapitre D'ouvrage Année : 2021

Aging and Senescence Processes in the Skeleton

Résumé

In all vertebrates and all skeletal parts, bone structure is strongly affected by aging and senescence, a situation that must be kept in mind when interpreting sections of osseous material from specimens of unknown age. Most of the knowledge on this topic deals with the human skeleton; however, available comparative data suggest that senescence processes are roughly similar in the skeletons of other mammals and, more loosely, other tetrapods. The present chapter describes the main, and best documented, consequences of aging on the morphological, microanatomical, architectural and histological features of the human and, to a lesser extent, the vertebrate skeleton. Structural as well as methodological questions are considered. Brief discussions are provided about the basic mechanisms, along with their possible genetic controls, that influence bone mass decrease with aging.
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Dates et versions

hal-03526695 , version 1 (14-01-2022)

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Catherine Bergot, Vivian de Buffrénil. Aging and Senescence Processes in the Skeleton. Vertebrate Skeletal Histology and Paleohistology, 1, CRC Press, 2021, ⟨10.1201/9781351189590⟩. ⟨hal-03526695⟩
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