%0 Conference Paper %F Oral %T Exposure driven risk assessment of nanoparticles: towards a re-equilibration of the traditional "risk = hazard x exposure" equation %+ Centre National de la Recherche Scientifique (CNRS) %+ Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE) %A Masion, A. %A de Garidel-Thoron, C. %A Pekar, S. %A Auffan, M. %A Rose, J. %A van Tongeren, M. %A Westerhof, P. %< avec comité de lecture %B 253rd ACS National Meeting %C San Francisco, CA, United States %8 2017-04-02 %D 2017 %Z Environmental SciencesConference papers %X As of today, the risk assessment associated with nanomaterials and their degradation products is most often addressed in terms of (eco)toxicity of the pristine nano-ingredient embebbed within these materials. Even when acquired properly in terms of doses and characterization efforts, these data barely represent the tip of the iceberg. Such a strategy is ill-adapted to account for the variety of (chemical) situations encountered along the life cycle of a given product and the alterations of the matrix containing the nano-ingredient. Here, we propose to consider exposure to the nano-ingredient as a factor as important as its intrinsic toxicity for the risk assessment of the products in order to implement a safe by design approach. Actual everyday products, such as cosmetics and paints, will serve as examples, as developped in national- (Labex SERENADE) and international projects (Nanoreg, Nanoreg 2, Prosafe, EU-US CoR %G English %L hal-03547483 %U https://cnrs.hal.science/hal-03547483 %~ SDE %~ INSU %~ CNRS %~ UNIV-AMU %~ CDF %~ CEREGE %~ OSU-INSTITUT-PYTHEAS %~ GIP-BE %~ PSL %~ INRAE %~ ED %~ CDF-PSL