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Chapitre D'ouvrage Année : 2016

Modifications in Therapeutic Oligonucleotides Improving the Delivery

Résumé

Oligonucleotides are increasingly used in clinical applications. RNA-based therapeutics include inhibitors of mRNA translation, agents of RNA interference, ribozymes, and aptamers targeting various molecular targets. Challenges with the delivery, specificity, and stability of these therapeutics have spawned the development of chemically modified oligonucleotides. In this chapter, we will describe modifications improving delivery and stability of RNA molecules in human cells. Because the most of the cell transfection methods using oligonucleotide complexes with cationic lipids revealed to be toxic, specific modifications and various conjugates have been recently developed to promote the carrier-free
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Dates et versions

hal-03561747 , version 1 (21-02-2022)

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Citer

Ilya Dovydenko, Alya Venyaminova, Dmitrii Pyshnyi, Ivan Tarassov, Nina Entelis. Modifications in Therapeutic Oligonucleotides Improving the Delivery. Stefan Jurga; Volker A. Erdmann; Jan Barciszewski. Modified Nucleic Acids in Biology and Medicine, Springer International Publishing, pp.319-337, 2016, RNA Technologies, ⟨10.1007/978-3-319-34175-0_14⟩. ⟨hal-03561747⟩

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