%0 Journal Article %T Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges %+ Technishe Universität Bergakademie Freiberg (TU Bergakademie Freiberg) %+ Institute of Bioorganic Chemistry [Poznań] %+ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) %+ Institute of Animal Physiology and Genetics of the Czech Academy of Sciences (IAPG / CAS) %+ Max Planck Institute for Chemical Physics of Solids (CPfS) %+ Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE) %+ Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE) %A Ehrlich, Hermann %A Luczak, Magdalena %A Ziganshin, Rustam %A Mikšík, Ivan %A Wysokowski, Marcin %A Simon, Paul %A Baranowska‐bosiacka, Irena %A Kupnicka, Patrycja %A Ereskovsky, Alexander %A Galli, Roberta %A Dyshlovoy, Sergey %A Fischer, Jonas %A Tabachnick, Konstantin %A Petrenko, Iaroslav %A Jesionowski, Teofil %A Lubkowska, Anna %A Figlerowicz, Marek %A Ivanenko, Viatcheslav %A Summers, Adam %< avec comité de lecture %@ 2198-3844 %J Advanced Science %I Wiley Open Access %V 9 %N 11 %P 2105059 %8 2022-02-14 %D 2022 %R 10.1002/advs.202105059 %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]Journal articles %X Actin is a fundamental member of an ancient superfamily of structural intracellular proteins and plays a crucial role in cytoskeleton dynamics, ciliogenesis, phagocytosis, and force generation in both prokaryotes and eukaryotes. It is shown that actin has another function in metazoans: patterning biosilica deposition, a role that has spanned over 500 million years. Species of glass sponges (Hexactinellida) and demosponges (Demospongiae), representatives of the first metazoans, with a broad diversity of skeletal structures with hierarchical architecture unchanged since the late Precambrian, are studied. By etching their skeletons, organic templates dominated by individual F-actin filaments, including branched fibers and the longest, thickest actin fiber bundles ever reported, are isolated. It is proposed that these actin-rich filaments are not the primary site of biosilicification, but this highly sophisticated and multi-scale form of biomineralization in metazoans is ptterned. %G English %2 https://cnrs.hal.science/hal-03571991/document %2 https://cnrs.hal.science/hal-03571991/file/Ehrlich%20et_2022%20-%20Actin.pdf %L hal-03571991 %U https://cnrs.hal.science/hal-03571991 %~ IRD %~ UNIV-AVIGNON %~ CNRS %~ UNIV-AMU %~ IMBE %~ OSU-INSTITUT-PYTHEAS %~ DFME