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Article Dans Une Revue Acta Neurologica Scandinavica Année : 2018

Pretherapeutic Functional Neuroimaging Predicts Tremor Arrest after Thalamotomy

C. Tuleasca
  • Fonction : Auteur
E. Najdenovska
  • Fonction : Auteur
J. Régis
  • Fonction : Auteur
T. Witjas
  • Fonction : Auteur
J. Champoudry
  • Fonction : Auteur
M. Faouzi
  • Fonction : Auteur
J.-P. Thiran
  • Fonction : Auteur
M. Bach Cuadra
  • Fonction : Auteur
M. Levivier
  • Fonction : Auteur
D. van De Ville
  • Fonction : Auteur

Résumé

Objective Essential tremor (ET) represents the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic procedures (deep brain stimulation or radiofrequency thalamotomy) or alternatively minimally invasive high-focused ultrasound or radiosurgery. All aim at same target, thalamic ventro-intermediate nucleus (Vim). Methods The study included a cohort of 17 consecutive patients, with ET, treated only with left unilateral stereotactic radiosurgical thalamotomy (SRS-T) between September 2014 and August 2015. The mean time to tremor improvement was 3.32 months (SD 2.7, 0.5-10). Neuroimaging data were collected at baseline (n = 17). Standard tremor scores, including activities of daily living (ADL) and tremor score on treated hand (TSTH), were completed pretherapeutically and 1 year later. We further correlate these scores with baseline inter-connectivity in twenty major large-scale brain networks. Results We report as predictive three networks, with the interconnected statistically significant clusters: primary motor cortex interconnected with inferior olivary nucleus, bilateral thalamus interconnected with motor cerebellum lobule V2 (ADL), and anterior default-mode network interconnected with Brodmann area 103 (TSTH). For all, more positive pretherapeutic interconnectivity correlated with higher drop in points on the respective scores. Age, disease duration, or time-to-response after SRS-T were not statistically correlated with pretherapeutic brain connectivity measures (P > .05). The same applied to pretherapeutic tremor scores, after using the same methodology described above. Conclusions Our findings have clinical implications for predicting clinical response after SRS-T. Here, using pretherapeutic magnetic resonance imaging and data processing without prior hypothesis, we show that pretherapeutic network(s) interconnectivity strength predicts tremor arrest in drug-na\"ive ET, following stereotactic radiosurgical thalamotomy.

Dates et versions

hal-03590345 , version 1 (27-02-2022)

Identifiants

Citer

C. Tuleasca, E. Najdenovska, J. Régis, T. Witjas, N. Girard, et al.. Pretherapeutic Functional Neuroimaging Predicts Tremor Arrest after Thalamotomy. Acta Neurologica Scandinavica, 2018, 137 (5), pp.500--508. ⟨10.1111/ane.12891⟩. ⟨hal-03590345⟩
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