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Article Dans Une Revue Oncotarget Année : 2018

Association between genetic polymorphisms and platinum-induced ototoxicity in children

Gabrielle Lui
  • Fonction : Auteur
Naïm Bouazza
  • Fonction : Auteur
Françoise Denoyelle
  • Fonction : Auteur
Laurence Brugières
  • Fonction : Auteur
Pascal Chastagner
  • Fonction : Auteur
  • PersonId : 759710
  • IdRef : 080522599
Nadège Corradini
  • Fonction : Auteur
Cécile Vérité
  • Fonction : Auteur
Judith Landmanparker
  • Fonction : Auteur
Hélène Sudour-Bonnange
  • Fonction : Auteur
Marlène Pasquet
Arnauld Verschuur
  • Fonction : Auteur
Cécile Faure-Conter
  • Fonction : Auteur
François Doz
  • Fonction : Auteur
Jean-Marc Tréluyer
  • Fonction : Auteur

Résumé

Platinum is extensively used in the treatment of several childhood cancers. However, ototoxicity is one of the most notable adverse effects, especially in children. Several studies suggest that genetics may predict its occurrence. Here, polymorphisms associated with platinum-induced ototoxicity were selected from the literature and were investigated in a pediatric population treated with platinum-based agents. In this retrospective study, patients treated with cisplatin and/or carboplatin were screened. The patients with pre- and post-treatment audiogram (Brock criteria) available were included. We selected polymorphisms that have previously been associated with cisplatin ototoxicity with a minor allele frequency ≥30%. Deletion of GSTM1 and GSTT1, rs1799735 (GSTM3), rs1695 (GSTP1), rs4880 (SOD2), rs2228001 (XPC), rs1799793 (XPD) and rs4788863 (SLC16A5) were investigated. Data of one hundred and six children matching the eligible criteria were analyzed. Thirty-three patients (31%) developed ototoxicity (with a Brock grade ≥2). The probability of hearing loss increased significantly in patients carrying the null genotype for GSTT1 (P = 0.03), A/A genotype at rs1695 (P = 0.01), and C/C genotype at rs1799793 (P = 0.008). We also showed an association of the cumulative doses of carboplatin with cisplatin ototoxicity (P <0.05). To conclude, deletion of GSTT1, rs1695 and rs1799793 may constitute potential predictors of platinum-induced ototoxicity.

Domaines

Cancer

Dates et versions

hal-03637853 , version 1 (11-04-2022)

Identifiants

Citer

Gabrielle Lui, Naïm Bouazza, Françoise Denoyelle, Laurence Brugières, Pascal Chastagner, et al.. Association between genetic polymorphisms and platinum-induced ototoxicity in children. Oncotarget, 2018, 9 (56), pp.30883-30893. ⟨10.18632/oncotarget.25767⟩. ⟨hal-03637853⟩

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