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Article Dans Une Revue Journal of Hematology and Oncology Année : 2021

COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Livio Pagano (1, 2) , Jon Salmanton-García (3, 4) , Francesco Marchesi (5) , Alessandro Busca (6) , Paolo Corradini (7) , Martin Hoenigl (8, 9) , Nikolai Klimko (10) , Philipp Koehler (11) , Antonio Pagliuca (12) , Francesco Passamonti (13) , Luisa Verga (14) , Benjamin Víšek (15) , Osman Ilhan (16) , Gianpaolo Nadali (17) , Barbora Weinbergerová (18) , Raúl Córdoba-Mascuñano (19) , Monia Marchetti (20) , Graham Collins (21) , Francesca Farina (22) , Chiara Cattaneo (23) , Alba Cabirta (24, 25) , Maria Gomes-Silva (26) , Federico Itri (27) , Jaap van Doesum (28) , Marie-Pierre Ledoux (29) , Martin Čerňan (30) , Ozren Jakšić (31) , Rafael Duarte (32) , Gabriele Magliano (33) , Ali Omrani (34) , Nicola Fracchiolla (35) , Austin Kulasekararaj (12) , Toni Valković (36, 37) , Christian Bjørn Poulsen (38) , Marina Machado (39) , Andreas Glenthøj (40) , Igor Stoma (41) , Zdeněk Ráčil (42) , Klára Piukovics (43) , Milan Navrátil (44) , Ziad Emarah (45) , Uluhan Sili (46) , Johan Maertens (47) , Ola Blennow (48) , Rui Bergantim (49, 50, 51, 52) , Carolina García-Vidal (53) , Lucia Prezioso (35) , Anna Guidetti (7) , Maria Ilaria del Principe (54) , Marina Popova (55) , Nick de Jonge (56) , Irati Ormazabal-Vélez (57) , Noemí Fernández (58) , Iker Falces-Romero (59) , Annarosa Cuccaro (60) , Stef Meers (61) , Caterina Buquicchio , Darko Antić (62, 63) , Murtadha Al-Khabori (64) , Ramón García-Sanz (65, 66) , Monika Biernat (67) , Maria Chiara Tisi (68) , Ertan Sal (11) , Laman Rahimli (11) , Natasa Čolović (63) , Martin Schönlein (69) , Maria Calbacho (70) , Carlo Tascini (71) , Carolina Miranda-Castillo (72) , Nina Khanna (73) , Gustavo-Adolfo Méndez , Verena Petzer (74) , Caroline Besson (75) , Rémy Duléry (76) , Sylvain Lamure (77, 78) , Marcio Nucci (79) , Giovanni Zambrotta (80, 81) , Pavel Žák (15) , Guldane Cengiz Seval (16) , Valentina Bonuomo (17) , Jiří Mayer (18) , Alberto López-García (19) , Maria Vittoria Sacchi (20) , Stephen Booth (82) , Fabio Ciceri (83) , Margherita Oberti (23) , Marco Salvini (84) , Macarena Izuzquiza (24, 25) , Raquel Nunes-Rodrigues (26) , Emanuele Ammatuna (28) , Aleš Obr (85) , Raoul Herbrecht (29) , Lucía Núñez-Martín-Buitrago (32) , Valentina Mancini (86) , Hawraa Shwaylia (34) , Mariarita Sciumè (35) , Jenna Essame (12) , Marietta Nygaard (37) , Josip Batinić (37, 87) , Yung Gonzaga (88) , Isabel Regalado-Artamendi (39) , Linda Katharina Karlsson (89) , Maryia Shapetska (90) , Michaela Hanakova (42) , Shaimaa El-Ashwah (45) , Zita Borbényi (43) , Gökçe Melis Çolak (46) , Anna Nordlander (48) , Giulia Dragonetti (1, 2) , Alessio Maria Edoardo Maraglino (1, 2) , Amelia Rinaldi (35) , Cristina de Ramón-Sánchez (66) , Oliver Cornely (3, 4, 91) , Jan Novák
1 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
3 University Hospital of Cologne [Cologne]
4 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
5 IRE - IFO - Istituto Nazionale Tumori Regina Elena [Roma]
6 A.O.U - Città della Salute e della Scienza di Torino
7 IRCCS Istituto Nazionale dei Tumori [Milano]
8 UC San Diego - University of California [San Diego]
9 Medical University of Graz
10 Odessa National I.I.Mechnikov University
11 Faculty of Medicine [Cologne]
12 KCH - King's College Hospital
13 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
14 Dipartimento di Medicina e Chirurgia = School of Medicine and Surgery [Monza]
15 Faculty of Medicine in Hradec Kralove [Republique Tchèque]
16 Ankara University School of Medicine [Turkey]
17 Azienda Ospedaliera Universitaria Integrata of Verona
18 MUNI - Masaryk University [Brno]
19 Fundación Jiménez Díaz
20 Ospedale SS Antonio e Biagio e Cesare Arrigo
21 Churchill Hospital Oxford Centre for Haematology
22 IRCCS San Raffaele Scientific Institute [Milan, Italie]
23 ASST Spedali Civili of Brescia,
24 VHIO - Vall d'Hebron Institute of Oncology [Barcelone]
25 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
26 IPO Porto - Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto
27 Ospedale San Luigi Gonzaga
28 UMCG - University Medical Center Groningen [Groningen]
29 ICANS - Institut de Cancérologie de Strasbourg Europe
30 Palacky University Olomouc
31 Dubrava University Hospital - Zagreb School of Medicine [Zagreb, Croatia]
32 Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain]
33 ASST Great Metropolitan Niguarda / ASST Grande Ospedale Metropolitano Niguarda [Milan, Italia]
34 Hamad Medical Corporation [Doha, Qatar]
35 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
36 University of Rijeka
37 CROHEM - Croatian Cooperative Group for Hematological Diseases
38 Zealand University Hospital [Roskilde, Denmark]
39 Hospital General Universitario "Gregorio Marañón" [Madrid]
40 Department of Clinical Microbiology [Rigshospitalet]
41 GSMU - Homieĺ State Medical University
42 Institute of Hematology and Blood Transfusion [Prague, Czech Republic]
43 University of Szeged [Szeged]
44 University Hospital Ostrava
45 Mansoura University [Egypt]
46 Marmara University [Kadıköy - İstanbul]
47 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
48 Karolinska University Hospital [Stockholm]
49 I3S - Instituto de Investigação e Inovação em Saúde
50 IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto
51 Hospital de São João [Porto]
52 FMUP - Faculdade de Medicina da Universidade do Porto
53 Clinic Barcelona Hospital Universitari
54 University of Rome Tor Vergata
55 Pavlov First Saint Petersburg State Medical University [St. Petersburg]
56 VUMC - Vrije Universiteit Medical Centre
57 Complejo Hospitalario de Navarra
58 Hospital Universitario Marqués de Valdecilla [Santander]
59 La Paz University Hospital
60 Azienda Usl Toscana centro [Firenze]
61 AZ Klina
62 KCS - Clinical Center of Serbia
63 University of Belgrade [Belgrade]
64 SQU - Sultan Qaboos University
65 Hospital Universitario de Salamanca
66 Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
67 UWr - University of Wrocław [Poland]
68 San Bortolo Hospital
69 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
70 Hospital Universitario 12 de Octubre [Madrid]
71 ASU FC - Azienda Sanitaria Universitaria Friuli Centrale
72 URJC - Universidad Rey Juan Carlos [Madrid]
73 Unibas - Université de Bâle = University of Basel = Basel Universität
74 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
75 CHV - Centre Hospitalier de Versailles André Mignot
76 CRSA - Centre de Recherche Saint-Antoine
77 IGMM - Institut de Génétique Moléculaire de Montpellier
78 Département Hématologie biologique [CHRU Montpellier]
79 UNIRIO - Universidade Federal do Estado do Rio de Janeiro
80 San Gerardo Hospital of Monza
81 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
82 Oxford NIHR Biomedical Research Centre
83 IRCCS Ospedale San Raffaele [Milan, Italy]
84 Assi Sette Llaghi Varese
85 University Hospital Olomouc [Czech Republic]
86 ASST Grande Ospedale Metropolitano Niguarda
87 University Hospital Centre Zagreb
88 Instituto Nacional do Câncer
89 Rigshospitalet [Copenhagen]
90 Republican Scientific and Practical Center (RSPC) for organ and Tissue Transplantation, Minsk
91 DZIF - German Centre for Infection Research
Philipp Koehler
Antonio Pagliuca
Barbora Weinbergerová
Raúl Córdoba-Mascuñano
Chiara Cattaneo
Federico Itri
Martin Čerňan
Ali Omrani
Austin Kulasekararaj
Igor Stoma
Klára Piukovics
Milan Navrátil
Ziad Emarah
Uluhan Sili
Ola Blennow
Nick de Jonge
Iker Falces-Romero
Annarosa Cuccaro
Stef Meers
Caterina Buquicchio
Murtadha Al-Khabori
Monika Biernat
Maria Chiara Tisi
Ertan Sal
Laman Rahimli
Natasa Čolović
Gustavo-Adolfo Méndez
Rémy Duléry
Jiří Mayer
Alberto López-García
Stephen Booth
Margherita Oberti
Aleš Obr
Jenna Essame
Yung Gonzaga
Linda Katharina Karlsson
Shaimaa El-Ashwah
Zita Borbényi
Jan Novák

Résumé

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients ( n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.
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hal-03642030 , version 1 (26-04-2022)

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Livio Pagano, Jon Salmanton-García, Francesco Marchesi, Alessandro Busca, Paolo Corradini, et al.. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). Journal of Hematology and Oncology, 2021, 14 (1), pp.168. ⟨10.1186/s13045-021-01177-0⟩. ⟨hal-03642030⟩
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