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Article Dans Une Revue Frontiers in Immunology Année : 2021

Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

E. Gallerani
  • Fonction : Auteur
D. Proietto
  • Fonction : Auteur
B. Dallan
  • Fonction : Auteur
M. Campagnaro
  • Fonction : Auteur
S. Pacifico
  • Fonction : Auteur
V. Albanese
  • Fonction : Auteur
E. Marzola
  • Fonction : Auteur
P. Marconi
  • Fonction : Auteur
A. Caputo
  • Fonction : Auteur
R. Gavioli
  • Fonction : Auteur
F. Nicoli
  • Fonction : Auteur

Résumé

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses.

Dates et versions

hal-03657268 , version 1 (02-05-2022)

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Citer

E. Gallerani, D. Proietto, B. Dallan, M. Campagnaro, S. Pacifico, et al.. Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.693054⟩. ⟨hal-03657268⟩

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