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Article Dans Une Revue Vaccines Année : 2021

Use of a novel peptide welding technology platform for the development of B- and T-cell epitope-based vaccines

Résumé

Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed tetrabranched derivatives for this purpose based on a novel peptide welding technology (PWT). PWTs provide molecular scaffolds for the efficient synthesis of ultrapure peptide dendrimers, which allow the delivery of multiple ligands within a single macromolecular structure. Peptide vaccines incorporating T-cell epitopes derived from melanoma and B-cell epitopes derived from human immunodeficiency virus, synthesized using this approach, elicited primary immune responses in vitro and in vivo. Subcutaneous administration of the B-cell epitope-based vaccines also elicited more potent humoral responses than subcutaneous administration of the corresponding peptides alone. Highly immunogenic peptide epitope-based vaccines can therefore be generated quickly and easily using a novel PWT.

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Vaccinologie
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hal-03658518 , version 1 (04-05-2022)

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F. Nicoli, S. Pacifico, E. Gallerani, E. Marzola, V. Albanese, et al.. Use of a novel peptide welding technology platform for the development of B- and T-cell epitope-based vaccines. Vaccines, 2021, 9 (5), pp.526. ⟨10.3390/vaccines9050526⟩. ⟨hal-03658518⟩

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