Adrenal gland‐released vasostatin‐I is a myocardial depressant factor - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue British Journal of Clinical Pharmacology Année : 2020

Adrenal gland‐released vasostatin‐I is a myocardial depressant factor

Résumé

Pheochromocytoma crisis is an exceptional consequence of the release of storage vesicles of the adrenal medulla. It is complicated by fulminant adrenergic myocarditis. It offers a unique opportunity to detect inotropic negative factors from neuroendocrine origin. Our objectives were (a) to describe a pheochromocytoma crisis, (b) to investigate in vivo myocardial depressant activities for the N-terminal 1-76 Chromogranin A-derived peptide, vasostatin-I (VS-I). A patient with a pheochromocytoma crisis was treated, including extracorporeal membrane oxygenation, until mass resection. Plasma concentrations of VS-I were time-dependently assessed with a specific immunoassay; correlations with invasive cardiovascular parameters were investigated. Increased VS-I concentrations were observed over 7 days until tumour resection. VS-I concentrations correlated positively with Chromogranin A levels, negatively with cardiac output and left ventricular stroke work index, but not with heart rate. This case illustrates the pharmacokinetics of VS-I in a pheochromocytoma crisis. It highlights myocardial depressant activity for this peptide at high concentrations.

Domaines

Autre [q-bio.OT]

Dates et versions

hal-03709516 , version 1 (29-06-2022)

Identifiants

Citer

Francis Schneider, Vincent Castelain, Jean‐etienne Herbrecht, Sophie Hellé, Marie-Hélène Metz-Boutigue. Adrenal gland‐released vasostatin‐I is a myocardial depressant factor. British Journal of Clinical Pharmacology, 2020, 86 (4), pp.825-828. ⟨10.1111/bcp.14173⟩. ⟨hal-03709516⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More