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Article Dans Une Revue Developmental Medicine and Child Neurology Année : 2022

Cerebral sinovenous thrombosis associated with head/neck infection in children: Clues for improved management

Résumé

Aim: To compare paediatric patients with cerebral sinovenous thrombosis (CSVT) with and without head/neck infection to improve management of the condition.Method: We conducted a bicentric retrospective study of consecutive children (neonates excluded) with radiologically confirmed CSVT, comparing children with a concurrent head/neck infection and children with other causes.Results: A total of 84 consecutive patients (46 males and 38 females) with a median age of 4 years 6 months (range 3 months–17 years 5 months) were included. Associated head/neck infection was identified in 65.4% of cases and represented the main identified CSVT aetiology. Children in the head/neck infection group displayed a milder clinical presentation and less extensive CSVT. Median time to complete recanalization was significantly shorter in this group (89 days [interquartile range 35–101] vs 112.5 days [interquartile range 83–177], p = 0.005). These findings were even more pronounced in the subgroup of patients with otogenic infection and no neurological sign.Interpretation: As CSVT in the setting of an otogenic infection and no neurological sign seems to represent a milder condition with a shorter course, these results suggest adapting current recommendations: consider earlier control imaging in paediatric otogenic CSVT, and shorter anticoagulant treatment if recanalization is obtained
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Dates et versions

hal-03711579 , version 1 (01-07-2022)

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Lucie Narcy, Sabine Durand, Marion Grimaud, Nicolas Leboucq, David Grevent, et al.. Cerebral sinovenous thrombosis associated with head/neck infection in children: Clues for improved management. Developmental Medicine and Child Neurology, In press, ⟨10.1111/dmcn.15331⟩. ⟨hal-03711579⟩
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